Research points to metabolic alkalosis, which is the key culprit for all Diabetic Foot Disease.
Metabolic alkalosis is present constantly due to sugar (hyperglycemia) which increases serum osmolality. The key remedy is to correct acid-base balance than diabetes.
Remarks:
Best remedy is to correct neutralize Alkalosis either by drug such as Acetazolamide to excrete Bicarbonate or by increasing the PCO2 by different methods.
Remarks:
I can provide a detailed research paper on enquiry. I welcome you to work with me to validate this theory acceptable and workable practically. As you know this have many valuable beneficial applications for long term health of patients.