Obesity, Fatty Liver and Metabolic Disorders can be linked one to another as they are closely inter-related. These disorders occur due to Liver over working to produce Fat from Sugar for storing unwantedly.
My research point to high level of Insulin in the blood under circulation is the cause for this abnormality. More the Insulin in circulation, more the problem. It is known that Liver is driven to convert sugar to Fat by looking at the Insulin level in blood. Consistent high Insulin production and circulation causes Obesity, Fatty Liver and Metabolic Disorders.
Without reducing the Insulin level how much one may take various steps to burn the fat it will not fully succeed. Liver will over work to produce Fat. Pancreas is stimulated to produce more and more Insulin to keep the Blood sugar level in the normal range.
Insulin resistance is the root cause and chief culprit of these metabolic disorders. Due Insulin resistance more and more Insulin is required to maintain the Blood Glucose level.
My Theory behind Insulin Resistance:
Because Insulin receptor sites at cellular level are plugged with another compound which has more affinity, Insulin is left out non-acting resulting in high Blood Sugar levels. This free insulin in Blood travels all over the body and in Liver it is sensed as more blood sugar is available in the system unutilized. Liver in turn synthesis this sugar to Fat for storage and future use. Depending on the body profile this Fat is deposited in the belly which results in an apple shape of the belly over a period of time. This Fat is the root cause for the Obesity, Fatty Liver and Metabolic disorders.
This steroid which has ability to block the Insulin at Insulin receptor sites is progesterone, a hormone. Excess of this hormone molecules in the body plays havoc on the Insulin receptor sites, neuro-receptor sites at synapses as it easily micks the target molecules. Precise mechanism by which progesterone causes insulin resistance is so far unknown and further research is going on. We welcome researchers on this area for collaboration..
Due to this Insulin resistance develops and Insulin is unable to open the gateway for the Glucose to enter in at the cellular level.
If the Blood Sugar level is not controlled within the range then the person is diagnosed with Diabetics.
Remedy:
According to my research, removing the unwanted Progesterone molecules from the Insulin receptor sites is the solution to the problem.
Mifepristone, an antiprogestogen receptor blocker and glucocorticoid receptor (GR) antagonism activity. This drug seems to be potentially very useful in reducing the Insulin Resistance.
Remarks:
I can provide a detailed research paper on enquiry. I welcome you to work with me to validate this theory acceptable and workable practically. As you know this have many valuable beneficial applications for long term health of patients.
