Parkinson’s Disease

Parkinson’s disease is said to be disorder of the central nervous system that affects movement often including tremors. Today’s science says that it is related to Dopamine deficiency which is correct, but today’s says further that the impulses of twitching are from Brain (due to dopamine deficiency) which is totally incorrect.

Hence present day understanding of this disease is incorrect.

Theory behind it: 

Dopamine is a neuro modulatory molecule that plays several important roles in cells. One of the important roles is centralized muscular motor control. It is an inhibitory transmitter present in all the muscular synoptic cleft. The deficiency of dopamine leads to inability to properly transfer inhibitory action potentials through synaptic cleft of all muscles.  The action potential is transferred to the muscle only after summation of all the inputs (excitatory and inhibitory). When both excitatory and inhibitory inputs are at small level there will no muscle movement and when excitatory is more the muscle  is activated and vice versa. When the inhibitory transmitter is weak, (deficiency leads to hyperexcitability of neurons and) there will be stray muscular stimulation (twitching / tremors) when that particular muscle is resting. When the subject likes to moves that muscle then there will be no twitching / tremors due to proper excitatory stimulation which takes control. Because of weak inhibitory transmitter it leads to continuous muscle stiffness and thereby pain due to continuous contraction.